Department of Drug Science and Technology

Selected research products

Armando LG, Baroetto Parisi R, Remani E, Esiliato M, Rolando C, Vinciguerra V, Diarassouba A, Cena C, Miglio G. (2022) Persistence to Medications for Benign Prostatic Hyperplasia/Benign Prostatic Obstruction-Associated Lower Urinary Tract Symptoms in the ASL TO4 Regione Piemonte (Italy). Healthcare (Basel, Switzerland) 10(12) [DOI  PMID]

Monge C, Stoppa I, Ferraris C, Bozza A, Battaglia L, Cangemi L, Miglio G, Pizzimenti S, Clemente N, Gigliotti CL, Boggio E, Dianzani U, Dianzani C. (2022) Parenteral Nanoemulsions Loaded with Combined Immuno- and Chemo-Therapy for Melanoma Treatment. Nanomaterials (Basel, Switzerland) 12(23) [DOI  PMID]

Bordano V, Kinsella GK, Cannito S, Dianzani C, Gigliotti CL, Stephens JC, Monge C, Bocca C, Rosa AC, Miglio G, Dianzani U, Findlay JBC, Benetti E. (2022) G protein-coupled receptor 21 in macrophages: An in vitro study. European journal of pharmacology 926 175018 [DOI  PMID]

Kinsella GK, Cannito S, Bordano V, Stephens JC, Rosa AC, Miglio G, Guaschino V, Iannaccone V, Findlay JBC, Benetti E. (2021) GPR21 Inhibition Increases Glucose-Uptake in HepG2 Cells. International journal of molecular sciences 22(19) [DOI  PMID]

Miglio G, Basso L, Armando LG, Traina S, Benetti E, Diarassouba A, Baroetto Parisi R, Esiliato M, Rolando C, Remani E, Cena C. (2021) A Network Approach for the Study of Drug Prescriptions: Analysis of Administrative Records from a Local Health Unit (ASL TO4, Regione Piemonte, Italy). International journal of environmental research and public health 18(9) [DOI  PMID]

Benetti E, Liberto E, Bressanello D, Bordano V, Rosa AC, Miglio G, Haxhi J, Pugliese G, Balducci S, Cordero C. (2020) Sedentariness and Urinary Metabolite Profile in Type 2 Diabetic Patients, a Cross-Sectional Study. Metabolites 10(5) [DOI  PMID]

Dianzani C, Monge C, Miglio G, Serpe L, Martina K, Cangemi L, Ferraris C, Mioletti S, Osella S, Gigliotti CL, Boggio E, Clemente N, Dianzani U, Battaglia L. (2020) Nanoemulsions as Delivery Systems for Poly-Chemotherapy Aiming at Melanoma Treatment. Cancers 12(5) [DOI  PMID]

Clemente N, Boggio E, Gigliotti LC, Raineri D, Ferrara B, Miglio G, Argenziano M, Chiocchetti A, Cappellano G, Trotta F, Caldera F, Capucchio MT, Yagi J, Rojo MJ, Reno F, Cavalli R, Dianzani C, Dianzani U. (2020) Immunotherapy of experimental melanoma with ICOS-Fc loaded in biocompatible and biodegradable nanoparticles. Journal of controlled release : official journal of the Controlled Release Society 320 112-124 [DOI  PMID]

Verta R, Grange C, Gurrieri M, Borga S, Nardini P, Argenziano M, Ghe C, Cavalli R, Benetti E, Miglio G, Bussolati B, Pini A, Rosa AC. (2019) Effect of Bilastine on Diabetic Nephropathy in DBA2/J Mice. International journal of molecular sciences 20(10) [DOI  PMID]

Rosa AC, Benetti E, Gallicchio M, Boscaro V, Cangemi L, Dianzani C, Miglio G. (2019) Analyzing Cysteine Site Neighbors in Proteins to Reveal Dimethyl Fumarate Targets. Proteomics 19(4) e1800301 [DOI  PMID]

Miglio G. (2018) Analysis of fumarate-sensitive proteins and sites by exploiting residue interaction networks. Amino acids 50(5) 647-652 [DOI  PMID]

Clemente N, Ferrara B, Gigliotti CL, Boggio E, Capucchio MT, Biasibetti E, Schiffer D, Mellai M, Annovazzi L, Cangemi L, Muntoni E, Miglio G, Dianzani U, Battaglia L, Dianzani C. (2018) Solid Lipid Nanoparticles Carrying Temozolomide for Melanoma Treatment. Preliminary In Vitro and In Vivo Studies. International journal of molecular sciences 19(2) [DOI  PMID]

Cocco M, Pellegrini C, Martinez-Banaclocha H, Giorgis M, Marini E, Costale A, Miglio G, Fornai M, Antonioli L, Lopez-Castejon G, Tapia-Abellan A, Angosto D, Hafner-Bratkovic I, Regazzoni L, Blandizzi C, Pelegrin P, Bertinaria M. (2017) Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease. Journal of medicinal chemistry 60(9) 3656-3671 [DOI  PMID]

Miglio G, Vitarelli G, Klein T, Benetti E. (2017) Effects of linagliptin on human immortalized podocytes: a cellular system to study dipeptidyl-peptidase 4 inhibition. British journal of pharmacology 174(9) 809-821 [DOI  PMID]

Veglia E, Pini A, Moggio A, Grange C, Premoselli F, Miglio G, Tiligada K, Fantozzi R, Chazot PL, Rosa AC. (2016) Histamine type 1-receptor activation by low dose of histamine undermines human glomerular slit diaphragm integrity. Pharmacological research 114 27-38 [DOI  PMID]

Garella D, Atlante S, Borretto E, Cocco M, Giorgis M, Costale A, Stevanato L, Miglio G, Cencioni C, Fernandez-de Gortari E, Medina-Franco JL, Spallotta F, Gaetano C, Bertinaria M. (2016) Design and synthesis of N-benzoyl amino acid derivatives as DNA methylation inhibitors. Chemical biology & drug design 88(5) 664-676 [DOI  PMID]

Cocco M, Miglio G, Giorgis M, Garella D, Marini E, Costale A, Regazzoni L, Vistoli G, Orioli M, Massulaha-Ahmed R, Detraz-Durieux I, Groslambert M, Py BF, Bertinaria M. (2016) Design, Synthesis, and Evaluation of Acrylamide Derivatives as Direct NLRP3 Inflammasome Inhibitors. ChemMedChem 11(16) 1790-803 [DOI  PMID]

Miglio G, Sabatino AD, Veglia E, Giraudo MT, Beccuti M, Cordero F. (2016) A computational analysis of S-(2-succino)cysteine sites in proteins. Biochimica et biophysica acta 1864(2) 211-8 [DOI  PMID]

Miglio G, Veglia E, Fantozzi R. (2015) Fumaric acid esters prevent the NLRP3 inflammasome-mediated and ATP-triggered pyroptosis of differentiated THP-1 cells. International immunopharmacology 28(1) 215-9 [DOI  PMID]

Cocco M, Garella D, Di Stilo A, Borretto E, Stevanato L, Giorgis M, Marini E, Fantozzi R, Miglio G, Bertinaria M. (2014) Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. Journal of medicinal chemistry 57(24) 10366-82 [DOI  PMID]

Miglio G, Rosa AC, Rattazzi L, Grange C, Camussi G, Fantozzi R. (2012) Protective effects of peroxisome proliferator-activated receptor agonists on human podocytes: proposed mechanisms of action. British journal of pharmacology 167(3) 641-53 [DOI  PMID]

Rosa AC, Rattazzi L, Miglio G, Collino M, Fantozzi R. (2012) Angiotensin II induces tumor necrosis factor-alpha expression and release from cultured human podocytes. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 61(4) 311-7 [DOI  PMID]

Collino M, Benetti E, Miglio G, Castiglia S, Rosa AC, Aragno M, Thiemermann C, Fantozzi R. (2011) Peroxisome proliferator-activated receptor beta/delta agonism protects the kidney against ischemia/reperfusion injury in diabetic rats. Free radical biology & medicine 50(2) 345-53 [DOI  PMID]

Miglio G, Rosa AC, Rattazzi L, Grange C, Collino M, Camussi G, Fantozzi R. (2011) The subtypes of peroxisome proliferator-activated receptors expressed by human podocytes and their role in decreasing podocyte injury. British journal of pharmacology 162(1) 111-25 [DOI  PMID]

Collino M, Aragno M, Castiglia S, Miglio G, Tomasinelli C, Boccuzzi G, Thiemermann C, Fantozzi R. (2010) Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation. British journal of pharmacology 160(8) 1892-902 [DOI  PMID]

Miglio G, Rosa AC, Rattazzi L, Collino M, Lombardi G, Fantozzi R. (2009) PPARgamma stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss. Neurochemistry international 55(7) 496-504 [DOI  PMID]

Miglio G, Rattazzi L, Rosa AC, Fantozzi R. (2009) PPARgamma stimulation promotes neurite outgrowth in SH-SY5Y human neuroblastoma cells. Neuroscience letters 454(2) 134-8 [DOI  PMID]

Collino M, Thiemermann C, Mastrocola R, Gallicchio M, Benetti E, Miglio G, Castiglia S, Danni O, Murch O, Dianzani C, Aragno M, Fantozzi R. (2008) Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus. Shock (Augusta, Ga.) 30(3) 299-307 [DOI  PMID]

Miglio G, Dianzani C, Fallarini S, Fantozzi R, Lombardi G. (2007) Stimulation of N-methyl-D-aspartate receptors modulates Jurkat T cell growth and adhesion to fibronectin. Biochemical and biophysical research communications 361(2) 404-9 [DOI  PMID]

Torres-Sanchez MI, Zaccaria C, Buzzi B, Miglio G, Lombardi G, Polito L, Russo G, Lay L. (2007) Synthesis and biological evaluation of phosphono analogues of capsular polysaccharide fragments from Neisseria meningitidis A. Chemistry (Weinheim an der Bergstrasse, Germany) 13(23) 6623-35 [DOI  PMID]

Lombardi G, Miglio G, Varsaldi F, Minassi A, Appendino G. (2007) Oxyhomologation of the amide bond potentiates neuroprotective effects of the endolipid N-palmitoylethanolamine. The Journal of pharmacology and experimental therapeutics 320(2) 599-606 [DOI  PMID]

Pirali T, Busacca S, Beltrami L, Imovilli D, Pagliai F, Miglio G, Massarotti A, Verotta L, Tron GC, Sorba G, Genazzani AA. (2006) Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents. Journal of medicinal chemistry 49(17) 5372-6 [DOI  PMID]

Varsaldi F, Miglio G, Scordo MG, Dahl ML, Villa LM, Biolcati A, Lombardi G. (2006) Impact of the CYP2D6 polymorphism on steady-state plasma concentrations and clinical outcome of donepezil in Alzheimer's disease patients. European journal of clinical pharmacology 62(9) 721-6 [DOI  PMID]

Chiocchetti A, Miglio G, Mesturini R, Varsaldi F, Mocellin M, Orilieri E, Dianzani C, Fantozzi R, Dianzani U, Lombardi G. (2006) Group I mGlu receptor stimulation inhibits activation-induced cell death of human T lymphocytes. British journal of pharmacology 148(6) 760-8 [DOI  PMID]

Miglio G, Varsaldi F, Lombardi G. (2005) Human T lymphocytes express N-methyl-D-aspartate receptors functionally active in controlling T cell activation. Biochemical and biophysical research communications 338(4) 1875-83 [DOI  PMID]

Rossi F, Lombardo F, Paglino A, Cassani C, Miglio G, Arca B, Rizzi M. (2005) Identification and biochemical characterization of the Anopheles gambiae 3-hydroxykynurenine transaminase. The FEBS journal 272(21) 5653-62 [DOI  PMID]

Miglio G, Varsaldi F, Dianzani C, Fantozzi R, Lombardi G. (2005) Stimulation of group I metabotropic glutamate receptors evokes calcium signals and c-jun and c-fos gene expression in human T cells. Biochemical pharmacology 70(2) 189-99 [DOI  PMID]

Lombardi G, Miglio G, Dianzani C, Mesturini R, Varsaldi F, Chiocchetti A, Dianzani U, Fantozzi R. (2004) Glutamate modulation of human lymphocyte growth: in vitro studies. Biochemical and biophysical research communications 318(2) 496-502 [DOI  PMID]

Miglio G, Varsaldi F, Francioli E, Battaglia A, Canonico PL, Lombardi G. (2004) Cabergoline protects SH-SY5Y neuronal cells in an in vitro model of ischemia. European journal of pharmacology 489(3) 157-65 [DOI  PMID]

Lombardi G, Miglio G, Canonico PL, Naldi P, Comi C, Monaco F. (2003) Abnormal response to glutamate of T lymphocytes from multiple sclerosis patients. Neuroscience letters 340(1) 5-8 [DOI  PMID]

Lombardi G, Varsaldi F, Miglio G, Papini MG, Battaglia A, Canonico PL. (2002) Cabergoline prevents necrotic neuronal death in an in vitro model of oxidative stress. European journal of pharmacology 457(2-3) 95-8 [DOI  PMID]

Courses

• Advances in Pharmacology
  Dottorato in Scienze Farmaceutiche e Biomolecolari
• Farmacocinetica e Metabolismo dei Farmaci (SSFO) - anno solare 2022/2023 (STF0116)
  Corsi di studio in
  Farmacia - Chimica e tecnologia farmaceutiche
• Farmacognosia (CTF) (FAR0023)
  Corsi di studio in
  Farmacia - Chimica e tecnologia farmaceutiche
• Farmacometrìa (STF0287)
  Corsi di studio in
  Farmacia - Chimica e tecnologia farmaceutiche
• Farmacoterapia (STF0054)
  Corsi di studio in
  Farmacia - Chimica e tecnologia farmaceutiche

Research topics

Research groups

• "Methodology"
• Gruppo di Ricerca sull’Impiego del Farmaco

Research projects

• Development of computational methods to predict protein succination

Activities in agenda

See my calendar

Academic bodies

• Commissione Biblioteca
• Commissione Didattica
• Commissione spazi
• Consiglio di Dipartimento

• Commissione Monitoraggio e Riesame del corso di laurea in Chimica e tecnologia farmaceutiche

Office hours