Department of Drug Science and Technology

Research products

All my research products

Selected research products

Multitarget antioxidant NO-donor organic nitrates: a novel approach to overcome nitrates tolerance
2022-01-01 Elisabetta Marini, Marta Giorgis, Barbara Rolando, Konstantin Chegaev https://iris.unito.it/handle/2318/1872841

N-[1,3-Dialkyl(aryl)-2-oxoimidazolidin-4-ylidene]-aryl(alkyl)sulphonamides as Novel Selective Human Cannabinoid Type 2 Receptor (hCB2R) Ligands; Insights into the Mechanism of Receptor Activation/Deactivation
2022-01-01 Gianquinto, Eleonora; Sodano, Federica; Rolando, Barbara; Kostrzewa, Magdalena; Allarà, Marco; Mahmoud, Ali Mokhtar; Kumar, Poulami; Spyrakis, Francesca; Ligresti, Alessia; Chegaev, Konstantin https://iris.unito.it/handle/2318/1880431

New Hydroxybenzoazole Inhibitors of Aldo-Keto Reductase 1C3 (AKR1C3): Disclosure of SAR Investigation to Target Prostate Cancer
2022-01-01 Chiara Vigato, Agnese Chiara Pippione, Iole Mannella, Mariia Iakovleva, Stefano Sainas, Simonetta Oliaro Bosso, Barbara Rolando, Sandra Kovachka, Francesca Spyrakis, Marco Lucio Lolli, Donatella Boschi https://iris.unito.it/handle/2318/1882160

Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety
2022-01-01 Sainas, Stefano; Giorgis, Marta; Circosta, Paola; Poli, Giulio; Alberti, Marta; Passoni, Alice; Gaidano, Valentina; Pippione, Agnese C; Vitale, Nicoletta; Bonanni, Davide; Rolando, Barbara; Cignetti, Alessandro; Ramondetti, Cristina; Lanno, Alessia; Ferraris, Davide M; Canepa, Barbara; Buccinnà, Barbara; Piccinini, Marco; Rizzi, Menico; Saglio, Giuseppe; Al-Karadaghi, Salam; Boschi, Donatella; Miggiano, Riccardo; Tuccinardi, Tiziano; Lolli, Marco L https://iris.unito.it/handle/2318/1878289

Galactosylated Prodrugs: A Strategy to Improve the Profile of Nonsteroidal Anti-Inflammatory Drugs
2022-01-01 Sodano, Federica; Cristiano, Claudia; Rolando, Barbara; Marini, Elisabetta; Lazzarato, Loretta; Cuozzo, Mariarosaria; Albrizio, Stefania; Russo, Roberto; Rimoli, Maria Grazia https://iris.unito.it/handle/2318/1885270

New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold
2022-01-01 Pippione A.C.; Kilic-Kurt Z.; Kovachka S.; Sainas S.; Rolando B.; Denasio E.; Pors K.; Adinolfi S.; Zonari D.; Bagnati R.; Lolli M.L.; Spyrakis F.; Oliaro-Bosso S.; Boschi D. https://iris.unito.it/handle/2318/1859921

Multitarget antioxidant NO-donor organic nitrates: a novel ap-proach to overcome nitrates tolerance, an ex vivo study
2022-01-01 Elisabetta Marini*, Marta Giorgis, Marta Leporati, Barbara Rolando, Konstantin Chegaev, Loretta Lazzarato, Massimo Bertinaria, Marco Vincenti, Antonella Di Stilo https://iris.unito.it/handle/2318/1842454

Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein
2022-01-01 Marini, Elisabetta; Marino, Marco; Gionfriddo, Giulia; Maione, Federica; Pandini, Marta; Oddo, Daniele; Giorgis, Marta; Rolando, Barbara; Blua, Federica; Gastaldi, Simone; Marchiò, Serena; Kovachka, Sandra; Spyrakis, Francesca; Gianquinto, Eleonora; Di Nicolantonio, Federica; Bertinaria, Massimo https://iris.unito.it/handle/2318/1882728

Multiple-targeting ligands for AKR1C3 enzyme and androgen receptor to target prostate cancer
2021-01-01 Agnese Chiara Pippione, Zuhal Kilic-Kurt, Stefano Sainas, Iole Mannella, Barbara Rolando, Sandra Kovachka, Francesca Spyrakis, Annamaria Buschini, Serena Montalbano, Simonetta Oliaro Bosso, Marco Lolli, Donatella Boschi https://iris.unito.it/handle/2318/1852081

New inhibitors of Aldo-Keto Reductase 1C3 (AKR1C3) based on benzoisoxazole scaffold and their potential application in cancer
2021-01-01 Mannella, Iole, Vigato, Chiara, Pasha, Rabia; Pippione Agnese Chiara, Sainas, Stefano, Oliaro Bosso Simonetta; Rolando, Barbara; Kovachka, Sandra, Spyrakis, Francesca; Boschi, Donatella, Lolli. Marco Lucio https://iris.unito.it/handle/2318/1852078

A generator of peroxynitrite activatable with red light
2021-01-01 Parisi C.; Failla M.; Fraix A.; Menilli L.; Moret F.; Reddi E.; Rolando B.; Spyrakis F.; Lazzarato L.; Fruttero R.; Gasco A.; Sortino S. https://iris.unito.it/handle/2318/1794858

Ketogal safety profile in human primary colonic epithelial cells and in mice
2021-01-01 Sodano F.; Avallone B.; Tizzano M.; Fogliano C.; Rolando B.; Gazzano E.; Riganti C.; Magliocca S.; Cuozzo M.; Albrizio S.; Calignano A.; Cristiano C.; Russo R.; Rimoli M.G. https://iris.unito.it/handle/2318/1824283

Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold: SAR of the Biphenyl Moiety
2021-01-01 Sainas S.; Giorgis M.; Circosta P.; Gaidano V.; Bonanni D.; Pippione A.C.; Bagnati R.; Passoni A.; Qiu Y.; Cojocaru C.F.; Canepa B.; Bona A.; Rolando B.; Mishina M.; Ramondetti C.; Buccinna B.; Piccinini M.; Houshmand M.; Cignetti A.; Giraudo E.; Al-Karadaghi S.; Boschi D.; Saglio G.; Lolli M.L. https://iris.unito.it/handle/2318/1795212

Tuning NO release of organelle-targeted furoxan derivatives and their cytotoxicity against lung cancer cells
2021-01-01 Sodano F.; Gazzano E.; Rolando B.; Marini E.; Lazzarato L.; Fruttero R.; Riganti C.; Gasco A. https://iris.unito.it/handle/2318/1794852

Extracellular matrix composition modulates the responsiveness of differentiated and stem pancreatic cancer cells to lipophilic derivate of gemcitabine
2021-01-01 Forciniti S.; Pozza E.D.; Greco M.R.; Carvalho T.M.A.; Rolando B.; Ambrosini G.; Carmona-Carmona C.A.; Pacchiana R.; Di Molfetta D.; Donadelli M.; Arpicco S.; Palmieri M.; Reshkin S.J.; Dando I.; Cardone R.A. https://iris.unito.it/handle/2318/1768821

Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide
2020-01-01 Sodano F.; Cavanagh R.J.; Pearce A.K.; Lazzarato L.; Rolando B.; Fraix A.; Abelha T.F.; Vasey C.E.; Alexander C.; Taresco V.; Sortino S. https://iris.unito.it/handle/2318/1743032

Coencapsulation of disulfiram and doxorubicin in liposomes strongly reverses multidrug resistance in breast cancer cells
2020-01-01 Rolle F.; Bincoletto V.; Gazzano E.; Rolando B.; Lollo G.; Stella B.; Riganti C.; Arpicco S. https://iris.unito.it/handle/2318/1747153

DNA-targeted NO release photoregulated by green light
2020-01-01 Cristina Parisi, Aurore Fraix, Stefano Guglielmo, Francesca Spyrakis, Barbara Rolando, https://iris.unito.it/handle/2318/1743323

In vitro vascular toxicity assessment of NitDOX, a novel NO-releasing doxorubicin
2020-01-01 Durante M.; Frosini M.; Fusi F.; Gamberucci A.; Chegaev K.; Rolando B.; Riganti C.; Fruttero R.; Saponara S. https://iris.unito.it/handle/2318/1746233

One molecule two goals: A selective P-glycoprotein modulator increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells
2020-01-01 Contino M.; Guglielmo S.; Riganti C.; Antonello G.; Perrone M.G.; Giampietro R.; Rolando B.; Fruttero R.; Colabufo N.A. https://iris.unito.it/handle/2318/1765848

Curcumin-loaded solid lipid nanoparticles bypass p-glycoprotein mediated doxorubicin resistance in triple negative breast cancer cells
2020-01-01 Abd-Ellatef G.-E.F.; Gazzano E.; Chirio D.; Hamed A.R.; Belisario D.C.; Zuddas C.; Peira E.; Rolando B.; Kopecka J.; Marie M.A.S.; Sapino S.; Fahmy S.R.; Gallarate M.; Abdel-Hamid A.-H.Z.; Riganti C. https://iris.unito.it/handle/2318/1740386

MRP5 nitration by NO-releasing gemcitabine encapsulated in liposomes confers sensitivity in chemoresistant pancreatic adenocarcinoma cells
2020-01-01 Masetto F.; Chegaev K.; Gazzano E.; Mullappilly N.; Rolando B.; Arpicco S.; Fruttero R.; Riganti C.; Donadelli M. https://iris.unito.it/handle/2318/1765395

Endoplasmic reticulum-targeting doxorubicin: a new tool effective against doxorubicin-resistant osteosarcoma
2019-01-01 Buondonno, Ilaria; Gazzano, Elena; Tavanti, Elisa; Chegaev, Konstantin; Kopecka, Joanna; Fanelli, Marilù; Rolando, Barbara; Fruttero, Roberta; Gasco, Alberto; Hattinger, Claudia; Serra, Massimo; Riganti, Chiara* https://iris.unito.it/handle/2318/1697821

Design, Biological Evaluation, and Molecular Modeling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-Glycoprotein Ligand Overcoming Multidrug Resistance in Cancer Stem Cells
2019-01-01 Riganti, Chiara; Contino, Marialessandra*; Guglielmo, Stefano; Perrone, Maria G.; Salaroglio, Iris C.; Milosevic, Vladan; Giampietro, Roberta; Leonetti, Francesco; Rolando, Barbara; Lazzarato, Loretta; Colabufo, Nicola A.; Fruttero, Roberta https://iris.unito.it/handle/2318/1697822

Preliminary ADME/PK studies of new hDHODH inhibitors effective for treatment of acute myeloid leukaemia (AML)
2019-01-01 Giulia De Simone, Stefano Sainas, Marilena Marraudino, Agnese Chiara https://iris.unito.it/handle/2318/1852024

Regioselective N‐Alkylation of Ethyl 4‐Benzyloxy‐1,2,3‐triazolecarboxylate: A Useful Tool for the Synthesis of Carboxylic Acid Bioisosteres
2019-01-01 Sainas, Stefano; Pippione, Agnese C.; Giraudo, Alessandro; Martina, Katia; Bosca, Federica; Rolando, Barbara; Barge, Alessandro; Ducime, Alex; Federico, Antonella; Grossert, Stuart J.; White, Robert L.; Boschi, Donatella; Lolli, Marco L. https://iris.unito.it/handle/2318/1686361

INCAPSULATED NO-GEMCITABINE: GASEOUS SOLUTION FOR MDR PANCREATIC CANCER
2019-01-01 Chegaev, K.; Masetto, F.; Gazzano, E.; Mullappily, N.; Rolando, B.; Donadelli, M.; Arpicco, S.; Riganti, C.; Fruttero, R. https://iris.unito.it/handle/2318/1707750

Paracetamol-Galactose Conjugate: A Novel Prodrug for an Old Analgesic Drug
2019-01-01 Sodano F.; Lazzarato L.; Rolando B.; Spyrakis F.; De Caro C.; Magliocca S.; Marabello D.; Chegaev K.; Gazzano E.; Riganti C.; Calignano A.; Russo R.; Rimoli M.G. https://iris.unito.it/handle/2318/1718832

EFFICIENTLY TARGETING DRUG EFFLUX THROUGH MODULATION OF P-GLYCOPROTEIN ACTIVITY BY SMALL MOLECULES: DESIGN, BIOLOGICAL AND COMPUTATIONAL STUDY.
2019-01-01 Stefano Guglielmo, Marialessandra Contino, Chiara Riganti, Barbara Rolando, Loretta Lazzarato https://iris.unito.it/handle/2318/1719781

Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3
2019-01-01 Lolli, Marco L; Carnovale, Irene M; Pippione, Agnese C; Wahlgren, Weixiao Y; Bonanni, Davide; Marini, Elisabetta; Zonari, Daniele; Gallicchio, Margherita; Boscaro, Valentina; Goyal, Parveen; Friemann, Rosmarie; Rolando, Barbara; Bagnati, Renzo; Adinolfi, Salvatore; Oliaro-Bosso, Simonetta; Boschi, Donatella https://iris.unito.it/handle/2318/1700881

Hyaluronated liposomes containing H2S-releasing doxorubicin are effective against P-glycoprotein-positive/doxorubicin-resistant osteosarcoma cells and xenografts
2019-01-01 Gazzano E.; Buondonno I.; Marengo A.; Rolando B.; Chegaev K.; Kopecka J.; Saponara S.; Sorge M.; Hattinger C.M.; Gasco A.; Fruttero R.; Brancaccio M.; Serra M.; Stella B.; Fattal E.; Arpicco S.; Riganti C. https://iris.unito.it/handle/2318/1712386

Preliminary ADME/PK studies of new hDHODH inhibitors effective for treatment of acute myeloid leukaemia (AML)
2019-01-01 Giulia De Simone, Stefano Sainas, Marilena Marraudino, Agnese Chiara Pippione, Brigitta Bonaldo, Alice Passoni, Marta Giorgis, Barbara Rolando, Donatella Boschi, Marco Lucio Lolli https://iris.unito.it/handle/2318/1721186

A molecular hybrid producing simultaneously singlet oxygen and nitric oxide by single photon excitation with green light
2019-01-01 Parisi, Cristina; Failla, Mariacristina; Fraix, Aurore; Rescifina, Antonio; Rolando, Barbara; Lazzarato, Loretta*; Cardile, Venera; Graziano, Adriana C.E.; Fruttero, Roberta; Gasco, Alberto; Sortino, Salvatore https://iris.unito.it/handle/2318/1685556

Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies
2019-01-01 Pippione, Agnese C; Sainas, Stefano; Goyal, Parveen; Fritzson, Ingela; Cassiano, Gustavo C; Giraudo, Alessandro; Giorgis, Marta; Tavella, Tatyana A; Bagnati, Renzo; Rolando, Barbara; Caing-Carlsson, Rhawnie; Costa, Fabio T M; Andrade, Carolina Horta; Al-Karadaghi, Salam; Boschi, Donatella; Friemann, Rosmarie; Lolli, Marco L https://iris.unito.it/handle/2318/1686362

Fluorescent Nitric Oxide Photodonors Based on BODIPY and Rhodamine Antennae
2019-01-01 Parisi C.; Failla M.; Fraix A.; Rolando B.; Gianquinto E.; Spyrakis F.; Gazzano E.; Riganti C.; Lazzarato L.; Fruttero R.; Gasco A.; Sortino S. https://iris.unito.it/handle/2318/1712387

Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells
2019-01-01 Salaroglio, Iris Chiara; Abate, Carmen; Rolando, Barbara; Battaglia, Luigi; Gazzano, Elena; Colombino, Elena; Costamagna, Costanzo; Annovazzi, Laura; Mellai, Marta; Berardi, Francesco; Capucchio, Maria Teresa; Schiffer, Davide; Riganti, Chiara https://iris.unito.it/handle/2318/1710693

Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters
2019-01-01 Giraudo A.; Krall J.; Bavo F.; Nielsen B.; Kongstad K.T.; Rolando B.; De Blasio R.; Gloriam D.E.; Loffler R.; Thiesen L.; Harpsoe K.; Frydenvang K.; Boschi D.; Wellendorph P.; Lolli M.L.; Jensen A.A.; Frolund B. https://iris.unito.it/handle/2318/1719861

Anti-pseudomonas activity of 3-nitro-4-phenylfuroxan
2018-01-01 Orlandi, Viviana Teresa*; Bolognese, Fabrizio; Rolando, Barbara; Guglielmo, Stefano; Lazzarato, Loretta; Fruttero, Roberta https://iris.unito.it/handle/2318/1685554

Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors
2018-01-01 Sainas, Stefano; Pippione, Agnese C; Lupino, Elisa; Giorgis, Marta; Circosta, Paola; Gaidano, Valentina; Goyal, Parveen; Bonanni, Davide; Rolando, Barbara; Cignetti, Alessandro; Ducime, Alex; Andersson, Mikael; Järvå, Michael; Friemann, Rosmarie; Piccinini, Marco; Ramondetti, Cristina; Buccinnà, Barbara; Al-Karadaghi, Salam; Boschi, Donatella; Saglio, Giuseppe; Lolli, Marco L https://iris.unito.it/handle/2318/1686360

Aceclofenac-galactose conjugate: design, synthesis, characterization and pharmacological and toxicological evaluations
2018-01-01 Magliocca, Salvatore; De Caro, Carmen; Lazzarato, Loretta; Russo, Roberto; Rolando, Barbara; Chegaev, Konstantin; Marini, Elisabetta; Nieddu, Maria; Burrai, Lucia; Boatto, Gianpiero; Cristiano, Claudia; Marabello, Domenica; Gazzano, Elena; Riganti, Chiara; Sodano, Federica; Rimoli, Maria Grazia https://iris.unito.it/handle/2318/1670027

New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands
2018-01-01 Contino, Marialessandra; Guglielmo, Stefano*; Perrone, Maria Grazia; Giampietro, Roberta; Rolando, Barbara; Carrieri, Antonio; Zaccaria, Daniele; Chegaev, Konstantin; Borio, Vanessa; Riganti, Chiara; Zabielska-Koczywas, Katarzyna; Colabufo, Nicola A.; Fruttero, Roberta https://iris.unito.it/handle/2318/1669830

Hyperglycemia Promotes Chemoresistance Through the Reduction of the Mitochondrial DNA Damage, the Bax/Bcl-2 and Bax/Bcl-XL Ratio, and the Cells in Sub-G1 Phase Due to Antitumoral Drugs Induced-Cytotoxicity in Human Colon Adenocarcinoma Cells.
2018-01-01 Loredana Bergandi, Eleonora Mungo, Rosa Morone, Ornella Bosco, https://iris.unito.it/handle/2318/1679031

Tuning the Hydrophobicity of a Mitochondria-Targeted NO Photodonor
2018-01-01 Sodano, Federica; Rolando, Barbara; Spyrakis, Francesca; Failla, Mariacristina; Lazzarato, Loretta*; Gazzano, Elena; Riganti, Chiara; Fruttero, Roberta; Gasco, Alberto; Sortino, Salvatore https://iris.unito.it/handle/2318/1670019

4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site
2018-01-01 Giraudo, Alessandro; Krall, Jacob; Nielsen, Birgitte; Sørensen, Troels E.; Kongstad, Kenneth T.; Rolando, Barbara; Boschi, Donatella; Frølund, Bente; Lolli, Marco L. https://iris.unito.it/handle/2318/1686358

Mitochondrial delivery of phenol substructure triggers mitochondrial depolarization and apoptosis of cancer cells
2018-01-01 Gazzano, Elena; Lazzarato, Loretta; Rolando, Barbara; Kopecka, Joanna; Guglielmo, Stefano; Costamagna, Costanzo; Chegaev, Konstantin*; Riganti, Chiara https://iris.unito.it/handle/2318/1669829

A Molecular Hybrid for Mitochondria-Targeted NO Photodelivery
2018-01-01 Sodano, Federica; Gazzano, Elena; Fraix, Aurore; Rolando, Barbara; Lazzarato, Loretta; Russo, Marina; Blangetti, Marco; Riganti, Chiara; Fruttero, Roberta; Gasco, Alberto; Sortino, Salvatore https://iris.unito.it/handle/2318/1656033

Folate-targeted liposomal nitrooxy-doxorubicin: An effective tool against P-glycoprotein-positive and folate receptor-positive tumors
2018-01-01 Gazzano, Elena; Rolando, Barbara; Chegaev, Konstantin; Salaroglio, Iris C.; Kopecka, Joanna; Pedrini, Isabella; Saponara, Simona; Sorge, Matteo; Buondonno, Ilaria; Stella, Barbara; Marengo, Alessandro; Valoti, Massimo; Brancaccio, Mara; Fruttero, Roberta; Gasco, Alberto; Arpicco, Silvia; Riganti, Chiara https://iris.unito.it/handle/2318/1657290

Light-Regulated NO Release as a Novel Strategy To Overcome Doxorubicin Multidrug Resistance
2017-01-01 Chegaev, Konstantin; Fraix, Aurore; Gazzano, Elena; Abd Ellatef, Gamal Eldein F.; Blangetti, Marco; Rolando, Barbara; Conoci, Sabrina; Riganti, Chiara; Fruttero, Roberta; Gasco, Alberto; Sortino, Salvatore https://iris.unito.it/handle/2318/1627517

gem-Dinitroalkyl Benzenes: A Novel Class of IOP-Lowering Agents for the Treatment of Ocular Hypertension
2017-01-01 Blangetti, Marco; Rolando, Barbara; Marini, Elisabetta; Chegaev, Konstantin; Guglielmo, Stefano; Lazzarato, Loretta; Laura, Lucarini; Emanuela, Masini; Fruttero, Roberta https://iris.unito.it/handle/2318/1650704

Furoxan nitric oxide donors disperse Pseudomonas aeruginosa biofilms, accelerate growth, and repress pyoverdine production
2017-01-01 Poh, Wee Han; Barraud, Nicolas; Guglielmo, Stefano; Lazzarato, Loretta; Fruttero, Roberta; Rolando, Barbara; Rice, Scott A. https://iris.unito.it/handle/2318/1647035

MODIFIED DOXORUBICINS: "GASEOUS APPROACH" TO OVERCOME CARDIOTOXICITY AND MULTIDRUG RESISTANCE
2016-01-01 Chegaev, K.; Rolando, B.; Gazzano, E.; Riganti, C.; Fruttero, R. https://iris.unito.it/handle/2318/1594821

In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition
2016-01-01 Malvina Hoxha; Buccellati, Carola; Capra, Valérie; Garella, Davide; Cena, Clara; Rolando, Barbara; Fruttero, Roberta; Carnevali, Silvia; Sala, Angelo; Rovati, G.Enrico; Bertinaria, Massimo. https://iris.unito.it/handle/2318/1551575

Overcoming multidrug resistance by targeting mitochondria with NO-donating doxorubicins
2016-01-01 Gazzano, Elena; Chegaev, Konstantin; Rolando, Barbara; Blangetti, Marco; Annaratone, Lorenzo; Ghigo, Dario; Fruttero, Roberta; Riganti, Chiara https://iris.unito.it/handle/2318/1556538

H2S-Donating Doxorubicins May Overcome Cardiotoxicity and Multidrug Resistance
2016-01-01 Chegaev, Konstantin; Rolando, Barbara; Cortese, Daniela; Gazzano, Elena; Buondonno, Ilaria; Lazzarato, Loretta; Fanelli, Marilù; Hattinger, Claudia M; Serra, Massimo; Riganti, Chiara; Fruttero, Roberta; Ghigo, Dario; Gasco, Alberto https://iris.unito.it/handle/2318/1570043

Quinone based nitric oxide donating compounds
2015-01-01 Marco, Blangetti; Roberta, Fruttero; Loretta, Lazzarato; Barbara, Rolando; Marta, Giorgis; Alberto, Gasco; Nicoletta, Almirante; Laura, Storoni https://iris.unito.it/handle/2318/1530732

Multitarget Drugs: No-Donor Doxorubicins
2015-01-01 Chegaev, Konstantin; Riganti, Chiara; Gazzano, Elena; Rolando, Barbara; Fruttero, Roberta; Gasco, Alberto https://iris.unito.it/handle/2318/1525583

Evaluation of the targeting ability of folate containing liposomal nitrooxy-doxorubicin.
2015-01-01 Pedrini, I.; Costamagna, F.; Buondonno, I.; Salaroglio, I. C.; Rolando, B.; Chegaev, K.; Fruttero, R.; Riganti, C.; Arpicco, S. https://iris.unito.it/handle/2318/1577366

NO-donor thiacarbocyanines as multifunctional agents for Alzheimer’s disease
2015-01-01 Chegaev, Konstantin; Federico, Antonella; Marini, Elisabetta; Rolando, Barbara; Fruttero, Roberta; Morbin, Michela; Rossi, Giacomina; Fugnanesi, Valeria; Bastone, Antonio; Salmona, Mario; Badiola, Nahuai B.; Gasparini, Laura; Cocco, Sara; Ripoli, Cristian; Grassi, Claudio; Gasco, Alberto https://iris.unito.it/handle/2318/1522113

An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells
2015-01-01 Campia, Ivana; Buondonno, Ilaria; Castella, Barbara; Rolando, Barbara; Kopecka, Joanna; Gazzano, Elena; Ghigo, Dario; Riganti, Chiara https://iris.unito.it/handle/2318/1520404

Novel NO-donor Doxorubicins
2014-01-01 Daniela Cortese; Konstantin Chegaev; Chiara Riganti; Barbara Rolando; Roberta Fruttero; Alberto Gasco. https://iris.unito.it/handle/2318/154553

Liposomal Nitrooxy-Doxorubicin: One Step over Caelyx in Drug-Resistant Human Cancer Cells
2014-01-01 Isabella Pedrini;Elena Gazzano;Konstantin Chegaev;Barbara Rolando;Alessandro Marengo;Joanna Kopecka;Roberta Fruttero;Dario Ghigo;Silvia Arpicco;Chiara Riganti https://iris.unito.it/handle/2318/148171

A multi-photoresponsive molecular-hybrid for dual-modal photoinactivation of cancer cells
2014-01-01 Aurore Fraix;Stefano Guglielmo;Venera Cardile;Adriana C. E. Graziano;Ruxandra Gref;Barbara Rolando;Roberta Fruttero;Alberto Gasco;Salvatore Sortino https://iris.unito.it/handle/2318/154501

New praziquantel derivatives containing NO-donor furoxans and related furazans as active agents against Schistosoma mansoni
2014-01-01 Stefano Guglielmo;Daniela Cortese;Francesca Vottero;Barbara Rolando;Valerie P. Kommer;David L. Williams;Roberta Fruttero;Alberto Gasco https://iris.unito.it/handle/2318/154502

NOVEL SEMISYNTHETIC DOXORUBICINS WITH REDUCED CARDIOTOXICITY
2013-01-01 Konstantin Chegaev; Loretta Lazzarato; Barbara Rolando; Chiara Riganti; Roberta Fruttero; Alberto Gasco https://iris.unito.it/handle/2318/138204

PREPARATION AND CHARACTERIZATION OF LIPOSOMES CONTAINING A NEW ANTHRACYCLINE DERIVATIVE
2013-01-01 Isabella Pedrini; Elena Gazzano; Silvia Arpicco; Chiara Riganti; Barbara Rolando; Konstantin Chegaev; Roberta Fruttero; Alberto Gasco https://iris.unito.it/handle/2318/140702

Water-Soluble Nitric-Oxide-Releasing Acetylsalicylic Acid
2013-01-01 Barbara Rolando; Loretta Lazzarato; Monica Donnola; Elisabetta Marini; Sony Joseph; Giuseppina Morini; Cristina Pozzoli;Roberta Fruttero; and Alberto Gasco https://iris.unito.it/handle/2318/140328

Mitochondrial-targeting nitrooxy-doxorubicin: a new approach to overcome drug resistance.
2013-01-01 Chiara Riganti; Barbara Rolando; Joanna Kopecka; Ivana Campia; Konstantin Chegaev; Loretta Lazzarato; Antonella Federico; Roberta Fruttero; Dario Ghigo https://iris.unito.it/handle/2318/129551

Doxorubicin-antioxidant multitarget drugs
2013-01-01 K Chegaev; C Riganti; B Rolando; L Lazzarato; E Gazzano; S Guglielmo; D Ghigo; R Fruttero; A Gasco https://iris.unito.it/handle/2318/137248

Novel R-roscovitine NO-donor hybrid compounds as potential
2013-01-01 Gabriele Montanaro; Massimo Bertinaria; Barbara Rolando; Roberta Fruttero; Christopher D. Lucas; David A. Dorward; Adriano G. Rossi; Ian L. Megson; Alberto Gasco https://iris.unito.it/handle/2318/132517

Preparation and characterization of liposomes containing a new anthracycline derivative.
2013-01-01 I. Pedrini; E Gazzano; S. Arpicco; C. Riganti; B. Rolando; K Chegaev; R. Fruttero; A. Gasco https://iris.unito.it/handle/2318/145192

Nitrooxy-doxorubicin: A New Weapon Against Multidrug Resistance.
2013-01-01 Joanna Kopecka; Chiara Riganti; Barbara Rolando; Ivana Campia; Konstantin Chegaev; Loretta Lazzarato; Antonella Federico; Roberta Fruttero; Dario Ghigo https://iris.unito.it/handle/2318/140707

Carnosine analogues containing Phenol substructures
2012-01-01 Giorgis M.; Bertinaria M.; Rolando B.; Montanaro G.; Fruttero R.; Gasco A. https://iris.unito.it/handle/2318/101094

Different multitarget approaches to manage coxibs associatedcardiovascular risk. Design and synthesis of new lumiracoxibderivatives
2012-01-01 M. Bertinaria; M. A. A. G. Shaikh; C. Cena; B. Rolando; L. Lazzarato; R. Fruttero; A. Gasco; G. E. Rovati; C. Buccellati; V. Capra; A. Sala https://iris.unito.it/handle/2318/119185

NITRIC OXIDE DONOR DOXORUBICINS: A USEFUL STRATEGY TO ADDRESS THE PROBLEM OF MDR IN CANCER THERAPY
2012-01-01 Rolando B.; Riganti C.; Chegaev K.; Fruttero R.; Gasco A. https://iris.unito.it/handle/2318/99312

Multitarget drugs: NO-donor doxorubicins
2012-01-01 Chegaev K.; Riganti C.; Rolando B.; Federico A.; Fruttero R.; Gasco A. https://iris.unito.it/handle/2318/98809

New class of NO-donor soluble aspirins
2012-01-01 Marini E.; Rolando B.; Lazzarato L.; Joseph S.; Fruttero R. https://iris.unito.it/handle/2318/101129

Designing Multitarget Anti-inflammatory Agents: Chemical Modulation of the Lumiracoxib Structure toward Dual Thromboxane Antagonists-COX-2 Inhibitors.
2012-01-01 Massimo Bertinaria; Mohammed Abrar Abdul Gaffar Shaikh; Carola Buccellati; Clara Cena; Barbara Rolando; Loretta Lazzarato; Roberta Fruttero; Alberto Gasco; Malvina Hoxha; Valrie Capra; Angelo Sala; G. Enrico Rovati https://iris.unito.it/handle/2318/120407

Carnosine analogues containing NO-donor substructures: Synthesis, physico-chemical characterization and preliminary pharmacological profile
2012-01-01 Bertinaria M; Rolando B; Giorgis M; Montanaro G; Marini E; Collino M; Benetti E; Daniele PG; Fruttero R; Gasco A. https://iris.unito.it/handle/2318/114076

Synthesis physicochemical profile and PAMPA study of new NO-donor edaravone co-drugs
2012-01-01 Barbara Rolando; Andrea Filieri; Konstantin Chegaev; Loretta Lazzarato; Marta Giorgis; Claudio De Nardi; Roberta Fruttero; Sophie Martel; Pierre-Alain Carrupt; Alberto Gasco https://iris.unito.it/handle/2318/93332

NO-donor Carnosine Derivatives As Potential Neuroprotective Agents
2011-01-01 Montanaro G.; Bertinaria M.; Giorgis M.; Rolando B.; Fruttero R.; Gasco A. https://iris.unito.it/handle/2318/92459

Synthesis, physico-chemical characterization, andbiological activities of new carnosine derivatives stablein human serum as potential neuroprotective agents
2011-01-01 Massimo Bertinaria; Barbara Rolando; Marta Giorgis; Gabriele Montanaro; Stefano Guglielmo; https://iris.unito.it/handle/2318/94458

Searching for new NO-donor aspirin-like molecules: furoxanylacyl derivatives of salicylic acid and related furazans
2011-01-01 Lazzarato Loretta; Cena Clara; Barbara Rolando; Elisabetta Marini; Marco Lucio Lolli; Guglielmo Stefano; Elena Guaita; Giuseppina Morini; Gabriella Coruzzi; Roberta Fruttero; Alberto Gasco https://iris.unito.it/handle/2318/131731

New nitric oxide or hydrogen sulfide releasing aspirins
2011-01-01 Loretta Lazzarato; Konstantin Chegaev; Elisabetta Marini; Barbara Rolando; Emily Borretto; Stefano Guglielmo; Sony Joseph; Antonella Di Stilo; Roberta Fruttero; Alberto Gasco https://iris.unito.it/handle/2318/93297

Amodiaquine analogues containing NO-donor substructures: Synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria
2011-01-01 Massimo Bertinaria; Stefano Guglielmo; Barbara Rolando; Marta Giorgis; Cristina Aragno; Roberta Fruttero; Alberto Gasco; Silvia Parapini; Donatella Taramelli; Yuri C. Martins; https://iris.unito.it/handle/2318/88173

1,2,5-Oxadiazole analogues of leflunomide and related compounds
2011-01-01 Marta Giorgis; Marco Lucio Lolli; Barbara Rolando; Angela Rao; Paolo Tosco; Shilpi Chaurasia; Domenica Marabello; Roberta Fruttero; Alberto Gasco. https://iris.unito.it/handle/2318/81665

Nitric Oxide Donor Doxorubicins Accumulate into Doxorubicin-Resistant Human Colon Cancer Cells Inducing Cytotoxicity
2011-01-01 Konstantin Chegaev; Chiara Riganti; Loretta Lazzarato; Barbara Rolando; Stefano Guglielmo; Ivana Campia; Roberta Fruttero; Amalia Bosia; Alberto Gasco https://iris.unito.it/handle/2318/88039

NO-Donor Furoxans Containing a Sulphonamide Moiety and Related Furazans as Potent Carbonic Anhydrase Inhibitors
2010-01-01 Roberta Fruttero; Loretta Lazzarato; Konstantin Chegaev; Barbara Rolando; Donatella Boschi; Claudiu T. Supuran; Alessio Innocenti; Alberto Gasco https://iris.unito.it/handle/2318/79067

Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs)
2010-01-01 Marco L. Lolli; Barbara Rolando; Paolo Tosco; Shilpi Chaurasia; Antonella Di Stilo; Loretta Lazzarato; Eva Gorassini; Riccardo Ferracini; Simonetta Oliaro-Bosso; Roberta Fruttero; Alberto Gasco https://iris.unito.it/handle/2318/71632

Nitrooxymethyl-Substituted Analogues of Rofecoxib: Synthesis and Pharmacological Characterization
2010-01-01 Donatella Boschi; Clara Cena; Antonella Di Stilo; Barbara Rolando; Paola Manzini; Roberta Fruttero; Alberto Gasco https://iris.unito.it/handle/2318/76135

4-Hydroxy-1,2,5-oxadiazol-3-yl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Molecular Pharmacological Characterization at Ionotropic Glutamate Receptors of Compounds Related to Glutamate and Its Homologues
2010-01-01 Marco L. Lolli; Cecilia Giordano; Darryl S. Pickering; Barbara Rolando; Kasper B. Hansen; Antonio Foti; Alberto Contreras-Sanz; Ahmad Amir; Roberta Fruttero; Alberto Gasco; Birgitte Nielsen; Tommy N. Johansen https://iris.unito.it/handle/2318/76221

Physicochemical profile and in vitro permeation behavior of a new class of non-steroidal anti-inflammatory drug candidates
2010-01-01 Barbara Rolando; Loretta Lazzarato; Antonella Di Stilo; Roberta Fruttero; Pierre-Alain Carrupt; Sophie Martel; Alberto Gasco https://iris.unito.it/handle/2318/73855

New No-donor aspirin derivatives
2009-01-01 R. FRUTTERO; A. GASCO; L. LAZZARATO; M. DONNOLA; B. ROLANDO; S. BIONDI https://iris.unito.it/handle/2318/27216

(Nitrooxyacyloxy)methyl esters of aspirin as novel nitric oxide releasing aspirins
2009-01-01 Loretta Lazzarato; Monica Donnola; Barbara Rolando; Konstantin Chegaev; Elisabetta Marini; Clara Cena; https://iris.unito.it/handle/2318/64090

NO-donor aspirin derivatives
2009-01-01 Alberto Gasco; Roberta Fruttero; Loretta Lazzarato; Barbara Rolando; Konstantin Chegaev; Monica Donnola; Ennio Ongini; Stefano Biondi https://iris.unito.it/handle/2318/80003

Unsymmetrically Substituted Furoxans. Part 19. Methyl and Phenylfuroxansulfonic Acids and Related Sulfonamides
2009-01-01 Konstantin Chegaev; Barbara Rolando; Stefano Guglielmo; Roberta Fruttero; Alberto Gasco https://iris.unito.it/handle/2318/62673

Courses

• Analisi dei Farmaci II (modulo del II semestre) (FAR0030)
  Corsi di studio in
  Farmacia - Chimica e tecnologia farmaceutiche
• Fitofarmacia e Analisi di Principi Attivi di Origine Vegetale (Tecniche Erboristiche) (FAR0252)
  Corso di Laurea in Tecniche Erboristiche
• Metodi di analisi dei farmaci (SSFO) - anno solare 2022/2023 (STF0120)
  Corsi di studio in
  Farmacia - Chimica e tecnologia farmaceutiche

Research groups

• 3D (Drug Design and Discovery) group
• SynBioMed (SBM)

Research projects

• Research of a new antitumor compounds active against chemo-resistant tumors
• Optimization of Oncology Therapy: Novel Drugs Affecting Multi Drug Resistance - CONCLUDED
• Study of New NO-Donor Compounds for the Potential Treatment of Glaucoma and Ocular Hypertension - CONCLUDED

Academic bodies

• Commissione Didattica
• Commissione Didattica Paritetica
• Commissione per gli orari delle lezioni
• Consiglio di Dipartimento
• Gruppo di lavoro AQ
• Referente AQ di Dipartimento

Office hours

Al termine delle lezioni o previo appuntamento (telefonico o e-mail)