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Anna Scomparin

Associate Professor

Contacts

At

  • Department of Drug Science and Technology
  • Dipartimento di Scienza e Tecnologia del Farmaco
  • Corsi di studio in
    Farmacia - Chimica e tecnologia farmaceutiche

Curriculum vitae

  • Curriculum Vitae (0.1 MB)

    • Selected research products

     

    1. Pozzi S, Scomparin A, Ben-Shushan D, Yeini E, Ofek P, Nahmad AD, Soffer S, Ionescu A, Ruggiero A, Barzel A, Brem H, Hyde TM, Barshack I, Sinha S, Ruppin E, Weiss T, Madi A, Perlson E, Slutsky I, Florindo HF, Satchi-Fainaro R. (2022) MCP-1/CCR2 axis inhibition sensitizes the brain microenvironment against melanoma brain metastasis progression. JCI insight 7(17) [DOI  PMID]
    2. Hananya N, Press O, Das A, Scomparin A, Satchi-Fainaro R, Sagi I, Shabat D. (2019) Persistent Chemiluminescent Glow of Phenoxy-dioxetane Luminophore Enables Unique CRET-Based Detection of Proteases. Chemistry (Weinheim an der Bergstrasse, Germany) 25(64) 14679-14687 [DOI  PMID]
    3. Doron H, Amer M, Ershaid N, Blazquez R, Shani O, Lahav TG, Cohen N, Adler O, Hakim Z, Pozzi S, Scomparin A, Cohen J, Yassin M, Monteran L, Grossman R, Tsarfaty G, Luxenburg C, Satchi-Fainaro R, Pukrop T, Erez N. (2019) Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis. Cell reports 28(7) 1785-1798.e6 [DOI  PMID]
    4. Malfanti A, Scomparin A, Pozzi S, Gibori H, Krivitsky A, Blau R, Satchi-Fainaro R, Mastrotto F, Caliceti P, Salmaso S. (2019) Oligo-guanidyl targeted bioconjugates forming rod shaped polyplexes as a new nanoplatform for oligonucleotide delivery. Journal of controlled release : official journal of the Controlled Release Society 310 58-73 [DOI  PMID]
    5. Conniot J, Scomparin A, Peres C, Yeini E, Pozzi S, Matos AI, Kleiner R, Moura LIF, Zupancic E, Viana AS, Doron H, Gois PMP, Erez N, Jung S, Satchi-Fainaro R, Florindo HF. (2019) Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators. Nature nanotechnology 14(9) 891-901 [DOI  PMID]
    6. Matos AI, Carreira B, Peres C, Moura LIF, Conniot J, Fourniols T, Scomparin A, Martinez-Barriocanal A, Arango D, Conde JP, Preat V, Satchi-Fainaro R, Florindo HF. (2019) Nanotechnology is an important strategy for combinational innovative chemo-immunotherapies against colorectal cancer. Journal of controlled release : official journal of the Controlled Release Society 307 108-138 [DOI  PMID]
    7. Gnaim S, Scomparin A, Eldar-Boock A, Bauer CR, Satchi-Fainaro R, Shabat D. (2019) Light emission enhancement by supramolecular complexation of chemiluminescence probes designed for bioimaging. Chemical science 10(10) 2945-2955 [DOI  PMID]
    8. Krivitsky A, Krivitsky V, Polyak D, Scomparin A, Eliyahu S, Gibori H, Yeini E, Pisarevsky E, Blau R, Satchi-Fainaro R. (2018) Molecular Weight-Dependent Activity of Aminated Poly(alpha)glutamates as siRNA Nanocarriers. Polymers 10(5) [DOI  PMID]
    9. Malfanti A, Mastrotto F, Han Y, Kral P, Balasso A, Scomparin A, Pozzi S, Satchi-Fainaro R, Salmaso S, Caliceti P. (2019) Novel Oligo-Guanidyl-PEG Carrier Forming Rod-Shaped Polyplexes. Molecular pharmaceutics 16(4) 1678-1693 [DOI  PMID]
    10. Blau R, Epshtein Y, Pisarevsky E, Tiram G, Israeli Dangoor S, Yeini E, Krivitsky A, Eldar-Boock A, Ben-Shushan D, Gibori H, Scomparin A, Green O, Ben-Nun Y, Merquiol E, Doron H, Blum G, Erez N, Grossman R, Ram Z, Shabat D, Satchi-Fainaro R. (2018) Image-guided surgery using near-infrared Turn-ON fluorescent nanoprobes for precise detection of tumor margins. Theranostics 8(13) 3437-3460 [DOI  PMID]
    11. Acurcio RC, Scomparin A, Conniot J, Salvador JAR, Satchi-Fainaro R, Florindo HF, Guedes RC. (2018) Structure-Function Analysis of Immune Checkpoint Receptors to Guide Emerging Anticancer Immunotherapy. Journal of medicinal chemistry 61(24) 10957-10975 [DOI  PMID]
    12. Gnaim S, Scomparin A, Das S, Blau R, Satchi-Fainaro R, Shabat D. (2018) Direct Real-Time Monitoring of Prodrug Activation by Chemiluminescence. Angewandte Chemie (International ed. in English) 57(29) 9033-9037 [DOI  PMID]
    13. Krivitsky A, Polyak D, Scomparin A, Eliyahu S, Ofek P, Tiram G, Kalinski H, Avkin-Nachum S, Feiner Gracia N, Albertazzi L, Satchi-Fainaro R. (2018) Amphiphilic poly(alpha)glutamate polymeric micelles for systemic administration of siRNA to tumors. Nanomedicine : nanotechnology, biology, and medicine 14(2) 303-315 [DOI  PMID]
    14. Ferber S, Tiram G, Sousa-Herves A, Eldar-Boock A, Krivitsky A, Scomparin A, Yeini E, Ofek P, Ben-Shushan D, Vossen LI, Licha K, Grossman R, Ram Z, Henkin J, Ruppin E, Auslander N, Haag R, Calderon M, Satchi-Fainaro R. (2017) Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome. eLife 6 [DOI  PMID]
    15. Silva AL, Peres C, Conniot J, Matos AI, Moura L, Carreira B, Sainz V, Scomparin A, Satchi-Fainaro R, Preat V, Florindo HF. (2017) Nanoparticle impact on innate immune cell pattern-recognition receptors and inflammasomes activation. Seminars in immunology 34 3-24 [DOI  PMID]
    16. Scomparin A, Florindo HF, Tiram G, Ferguson EL, Satchi-Fainaro R. (2017) Two-step polymer- and liposome-enzyme prodrug therapies for cancer: PDEPT and PELT concepts and future perspectives. Advanced drug delivery reviews 118 52-64 [DOI  PMID]
    17. Ferguson EL, Scomparin A, Hailu H, Satchi-Fainaro R. (2017) HPMA copolymer-phospholipase C and dextrin-phospholipase A2 as model triggers for polymer enzyme liposome therapy (PELT). Journal of drug targeting 25(9-10) 818-828 [DOI  PMID]
    18. Shatsberg Z, Zhang X, Ofek P, Malhotra S, Krivitsky A, Scomparin A, Tiram G, Calderon M, Haag R, Satchi-Fainaro R. (2016) Functionalized nanogels carrying an anticancer microRNA for glioblastoma therapy. Journal of controlled release : official journal of the Controlled Release Society 239 159-68 [DOI  PMID]
    19. Gnaim S, Scomparin A, Li X, Baran PS, Rader C, Satchi-Fainaro R, Shabat D. (2016) Tagging the Untaggable: A Difluoroalkyl-Sulfinate Ketone-Based Reagent for Direct C-H Functionalization of Bioactive Heteroarenes. Bioconjugate chemistry 27(9) 1965-71 [DOI  PMID]
    20. Krivitsky A, Polyak D, Scomparin A, Eliyahu S, Ori A, Avkin-Nachum S, Krivitsky V, Satchi-Fainaro R. (2016) Structure-Function Correlation of Aminated Poly(alpha)glutamate as siRNA Nanocarriers. Biomacromolecules 17(9) 2787-800 [DOI  PMID]
    21. Polyak D, Krivitsky A, Scomparin A, Eliyahu S, Kalinski H, Avkin-Nachum S, Satchi-Fainaro R. (2017) Systemic delivery of siRNA by aminated poly(alpha)glutamate for the treatment of solid tumors. Journal of controlled release : official journal of the Controlled Release Society 257 132-143 [DOI  PMID]
    22. Golan M, Feinshtein V, Polyak D, Scomparin A, Satchi-Fainaro R, David A. (2016) Inhibition of Gene Expression and Cancer Cell Migration by CD44v3/6-Targeted Polyion Complexes. Bioconjugate chemistry 27(4) 947-60 [DOI  PMID]
    23. Scomparin A, Polyak D, Krivitsky A, Satchi-Fainaro R. (2015) Achieving successful delivery of oligonucleotides--From physico-chemical characterization to in vivo evaluation. Biotechnology advances 33(6 Pt 3) 1294-309 [DOI  PMID]
    24. Scomparin A, Salmaso S, Eldar-Boock A, Ben-Shushan D, Ferber S, Tiram G, Shmeeda H, Landa-Rouben N, Leor J, Caliceti P, Gabizon A, Satchi-Fainaro R. (2015) A comparative study of folate receptor-targeted doxorubicin delivery systems: dosing regimens and therapeutic index. Journal of controlled release : official journal of the Controlled Release Society 208 106-20 [DOI  PMID]
    25. Ben-Shushan D, Markovsky E, Gibori H, Tiram G, Scomparin A, Satchi-Fainaro R. (2014) Overcoming obstacles in microRNA delivery towards improved cancer therapy. Drug delivery and translational research 4(1) 38-49 [DOI  PMID]
    26. Bonzi G, Salmaso S, Scomparin A, Eldar-Boock A, Satchi-Fainaro R, Caliceti P. (2015) Novel pullulan bioconjugate for selective breast cancer bone metastases treatment. Bioconjugate chemistry 26(3) 489-501 [DOI  PMID]
    27. Salmaso S, Bersani S, Scomparin A, Balasso A, Brazzale C, Barattin M, Caliceti P. (2014) A novel soluble supramolecular system for sustained rh-GH delivery. Journal of controlled release : official journal of the Controlled Release Society 194 168-77 [DOI  PMID]
    28. Tiram G, Scomparin A, Ofek P, Satchi-Fainaro R. (2014) Interfering cancer with polymeric siRNA nanomedicines. Journal of biomedical nanotechnology 10(1) 50-66 [DOI  PMID]
    29. Eldar-Boock A, Polyak D, Scomparin A, Satchi-Fainaro R. (2013) Nano-sized polymers and liposomes designed to deliver combination therapy for cancer. Current opinion in biotechnology 24(4) 682-9 [DOI  PMID]
    30. Markovsky E, Baabur-Cohen H, Eldar-Boock A, Omer L, Tiram G, Ferber S, Ofek P, Polyak D, Scomparin A, Satchi-Fainaro R. (2012) Administration, distribution, metabolism and elimination of polymer therapeutics. Journal of controlled release : official journal of the Controlled Release Society 161(2) 446-60 [DOI  PMID]
    31. Scomparin A, Salmaso S, Bersani S, Satchi-Fainaro R, Caliceti P. (2011) Novel folated and non-folated pullulan bioconjugates for anticancer drug delivery. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 42(5) 547-58 [DOI  PMID]
    32. Salmaso S, Bersani S, Scomparin A, Mastrotto F, Scherpfer R, Tonon G, Caliceti P. (2009) Tailored PEG for rh-G-CSF analogue site-specific conjugation. Bioconjugate chemistry 20(6) 1179-85 [DOI  PMID]

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