Department of Drug Science and Technology

Selected research products

Monge, C., Stoppa, I., Ferraris, C., Bozza, A., Battaglia, L., Cangemi, L., Miglio, G., Pizzimenti, S., Clemente, N., Gigliotti, C.L., Boggio, E., Dianzani, U., Dianzani, C. Parenteral Nanoemulsions Loaded with Combined Immuno- and Chemo-Therapy for Melanoma Treatment (2022) Nanomaterials, 12 (23), art. no. 4233, .  

Bozza, A., Campi, C., Garelli, S., Ugazio, E., Battaglia, L. Current regulatory and market frameworks in green cosmetics: The role of certification (2022) Sustainable Chemistry and Pharmacy, 30, art. no. 100851, .  

Liu, X., Wu, Z., Manzoli, M., Jicsinszky, L., Cavalli, R., Battaglia, L., Cravotto, G. Medium-high frequency sonication dominates spherical-SiO2 nanoparticle size (2022) Ultrasonics Sonochemistry, 90, art. no. 106181, .  

Battaglia, L.S., Dorati, R., Maestrelli, F., Conti, B., Gabriele, M., Di Cesare Mannelli, L., Selmin, F., Cosco, D.Repurposing of parenterally administered active substances used to treat pain both systemically and locally(2022) Drug Discovery Today, 27 (10), art. no. 103321, .  

Muntoni, E., Marini, E., Ferraris, C., Garelli, S., Capucchio, M.T., Colombino, E., Panciani, P.P., Battaglia, L.Intranasal lipid nanocarriers: Uptake studies with fluorescently labeled formulations (2022) Colloids and Surfaces B: Biointerfaces, 214, art. no. 112470, .

Gabano, E., Ferraris, C., Osella, D., Battaglia, L.S., Ravera, M. Formulations of highly antiproliferative hydrophobic Pt(IV) complexes into lipidic nanoemulsions as delivery vehicles (2022) Inorganica Chimica Acta, 535, art. no. 120859, .

Battaglia, L., Scomparin, A., Dianzani, C., Milla, P., Muntoni, E., Arpicco, S., Cavalli, R. Nanotechnology addressing cutaneous melanoma: The italian landscape (2021) Pharmaceutics, 13 (10), art. no. 1617, .

Gómez-Aguado, I., Rodríguez-Castejón, J., Beraza-Millor, M., Vicente-Pascual, M., Rodríguez-Gascón, A., Garelli, S., Battaglia, L., Del Pozo-Rodríguez, A., Solinís, M.Á. Mrna-based nanomedicinal products to address corneal inflammation by interleukin-10 supplementation (2021) Pharmaceutics, 13 (9), art. no. 1472, .

Ferraris, C., Rimicci, C., Garelli, S., Ugazio, E., Battaglia, L. Nanosystems in cosmetic products: A brief overview of functional, market, regulatory and safety concerns (2021) Pharmaceutics, 13 (9), art. no. 1408, .

Muntoni, E., Anfossi, L., Milla, P., Marini, E., Ferraris, C., Capucchio, M.T., Colombino, E., Segale, L., Porta, M., Battaglia, L. Glargine insulin loaded lipid nanoparticles: Oral delivery of liquid and solid oral dosage forms (2021) Nutrition, Metabolism and Cardiovascular Diseases, 31 (2), pp. 691-698.

Zanin, L., Saraceno, G., Renisi, G., Signorini, L., Battaglia, L., Ferrara, M., Rasulo, F.A., Panciani, P.P., Fontanella, M.M. Delayed onset of fatal encephalitis in a COVID-19 positive patient (2021) International Journal of Neuroscience, .

Perrelli, A., Fatehbasharzad, P., Benedetti, V., Ferraris, C., Fontanella, M., De Luca, E., Moglianetti, M., Battaglia, L., Retta, S.F. Towards precision nanomedicine for cerebrovascular diseases with emphasis on Cerebral Cavernous Malformation (CCM) (2021) Expert Opinion on Drug Delivery, 18 (7), pp. 849-876.

Vicente-Pascual, M.; Gómez-Aguado, I.; Rodríguez-Castejón, J.; Rodríguez-Gascón, A.; Muntoni, E.; Battaglia, L.; Del Pozo-Rodríguez, A.; Solinís Aspiazu, M.Á. Topical Administration of SLN-Based Gene Therapy for the Treatment of Corneal Inflammation by De Novo IL-10 Production. (2020) Pharmaceutics 12(6), 584.

Panciani, P.P.; Saraceno, G.; Zanin, L.; Renisi, G.; Signorini, L.; Battaglia, L.; Fontanella, M.M. SARS-CoV-2: "Three-steps" infection model and CSF diagnostic implication. (2020) Brain Behav Immun, 87, 128-129.

Dianzani, C., Monge, C., Miglio, G., Serpe, L., Martina, K., Cangemi, L., Ferraris, C., Violetti, S., Osella, S., Gigliotti, C.L., Boggi, E., Clemente, N., Dianzani, U., and Battaglia, L. Nanoemulsions as Delivery Systems for Poly-Chemotherapy Aiming at Melanoma Treatment (2020) Cancers, 12, 1198.

Ferraris, C., Cavalli, R., Panciani, P.P., Battaglia, L. Overcoming the blood–brain barrier: Successes and challenges in developing nanoparticle-mediated drug delivery systems for the treatment of brain tumours (2020) International Journal of Nanomedicine, 15, pp. 2999-3022.

del Pozo-Rodríguez, A., Rodríguez-Gascón, A., Rodríguez-Castejón, J., Vicente-Pascual, M., Gómez-Aguado, I., Battaglia, L.S., Solinís, M.Á. Gene Therapy (2020) Advances in Biochemical Engineering/Biotechnology, 171, pp. 321-368.

Muntoni, E., Marini, E., Ahmadi, N., Milla, P., Ghè, C., Bargoni, A., Capucchio, M.T., Biasibetti, E., Battaglia, L. Lipid nanoparticles as vehicles for oral delivery of insulin and insulin analogs: preliminary ex vivo and in vivo studies (2019) Acta Diabetologica, 56 (12), pp. 1283-1292.

Salaroglio, I.C., Abate, C., Rolando, B., Battaglia, L., Gazzano, E., Colombino, E., Costamagna, C., Annovazzi, L., Mellai, M., Berardi, F., Capucchio, M.T., Schiffer, D., Riganti, C. Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells (2019) Molecular Pharmaceutics, 16 (8), pp. 3361-3373.

Muntoni, E., Martina, K., Marini, E., Giorgis, M., Lazzarato, L., Salaroglio, I.C., Riganti, C., Lanotte, M., Battaglia, L. Methotrexate-loaded solid lipid nanoparticles: Protein functionalization to improve brain biodistribution (2019) Pharmaceutics, 11 (2), art. no. 65, .

Battaglia, L., Ugazio, E. Lipid nano- and microparticles: An overview of patent-related research (2019) Journal of Nanomaterials, 2019, art. no. 2834941, .

Battaglia, L., Panciani, P.P., Muntoni, E., Capucchio, M.T., Biasibetti, E., De Bonis, P., Mioletti, S., Fontanella, M., Swaminathan, S. Lipid nanoparticles for intranasal administration: application to nose-to-brain delivery (2018) Expert Opinion on Drug Delivery, 15 (4), pp. 369-378.

Stella, B., Peira, E., Dianzani, C., Gallarate, M., Battaglia, L., Gigliotti, C.L., Boggio, E., Dianzani, U., Dosio, F. Development and characterization of solid lipid nanoparticles loaded with a highly active doxorubicin derivative (2018) Nanomaterials, 8 (2), art. no. 110, .

Clemente, N., Ferrara, B., Gigliotti, C.L., Boggio, E., Capucchio, M.T., Biasibetti, E., Schiffer, D., Mellai, M., Annovazzi, L., Cangemi, L., Muntoni, E., Miglio, G., Dianzani, U., Battaglia, L., Dianzani, C. Solid lipid nanoparticles carrying temozolomide for melanoma treatment. Preliminary in vitro and in vivo studies (2018) International Journal of Molecular Sciences, 19 (2), art. no. 255, .

Battaglia, L., Gallarate, M., Serpe, L., Foglietta, F., Muntoni, E., Rodriguez, A.P., Aspiazu, M.A.S. Ocular delivery of solid lipid nanoparticles (2018) Lipid Nanocarriers for Drug Targeting, pp. 269-312.

Chirio, D., Peira, E., Battaglia, L., Ferrara, B., Barge, A., Sapino, S., Giordano, S., Dianzani, C., Gallarate, M. Lipophilic prodrug of floxuridine loaded into solid lipid nanoparticles: In vitro cytotoxicity studies on different human cancer cell lines (2018) Journal of Nanoscience and Nanotechnology, 18 (1), pp. 556-563.

Vicente-Pascual, M., Albano, A., Solinís, M.Á., Serpe, L., Rodríguez-Gascón, A., Foglietta, F., Muntoni, E., Torrecilla, J., Pozo-Rodríguez, A.D., Battaglia, L. Gene delivery in the cornea: In vitro & ex vivo evaluation of solid lipid nanoparticle-based vectors (2018) Nanomedicine, 13 (15), pp. 1847-1864.

Biasibetti, E., Valazza, A., Capucchio, M.T., Annovazzi, L., Battaglia, L., Chirio, D., Gallarate, M., Mellai, M., Muntoni, E., Peira, E., Riganti, C., Schiffer, D., Panciani, P., Lanotte, M. Comparison of allogeneic and syngeneic rat glioma models by using MRI and histopathologic evaluation (2017) Comparative Medicine, 67 (2), pp. 147-156.

Battaglia, L., Muntoni, E., Chirio, D., Peira, E., Annovazzi, L., Schiffer, D., Mellai, M., Riganti, C., Salaroglio, I.C., Lanotte, M., Panciani, P., Capucchio, M.T., Valazza, A., Biasibetti, E., Gallarate, M. Solid lipid nanoparticles by coacervation loaded with a methotrexate prodrug: Preliminary study for glioma treatment (2017) Nanomedicine, 12 (6), pp. 639-656.

Annovazzi, L., Schiffer, D., Mellai, M., Gallarate, M., Battaglia, L., Chirio, D., Peira, E., Muntoni, E., Chegaev, K., Barge, A., Lanotte, M., Panciani, P., Capucchio, M.T., Valazza, A., Biasibetti, E., Riganti, C. Solid lipid nanoparticles loaded with antitumor lipophilic prodrugs aimed to glioblastoma treatment: Preliminary studies on cultured cells (2017) Journal of Nanoscience and Nanotechnology, 17 (5), pp. 3606-3614.

Battaglia, L., Serpe, L., Foglietta, F., Muntoni, E., Gallarate, M., Del Pozo Rodriguez, A., Solinis, M.A. Application of lipid nanoparticles to ocular drug delivery (2016) Expert Opinion on Drug Delivery, 13 (12), pp. 1743-1757.

Peira, E., Chirio, D., Battaglia, L., Barge, A., Chegaev, K., Gigliotti, C.L., Ferrara, B., Dianzani, C., Gallarate, M. Solid lipid nanoparticles carrying lipophilic derivatives of doxorubicin: preparation, characterization, and in vitro cytotoxicity studies (2016) Journal of Microencapsulation, 33 (4), pp. 381-390.

Arpicco, S., Battaglia, L., Brusa, P., Cavalli, R., Chirio, D., Dosio, F., Gallarate, M., Milla, P., Peira, E., Rocco, F., Sapino, S., Stella, B., Ugazio, E., Ceruti, M. Recent studies on the delivery of hydrophilic drugs in nanoparticulate systems (2016) Journal of Drug Delivery Science and Technology, 32, pp. 298-312.

Battaglia, L., Gallarate, M., Peira, E., Chirio, D., Solazzi, I., Giordano, S.M.A., Gigliotti, C.L., Riganti, C., Dianzani, C. Bevacizumab loaded solid lipid nanoparticles prepared by the coacervation technique: Preliminary in vitro studies (2015) Nanotechnology, 26 (25), art. no. 255102, .

Annovazzi, L., Caldera, V., Mellai, M., Riganti, C., Battaglia, L., Chirio, D., Melcarne, A., Schiffer, D. The DNA damage/repair cascade in glioblastoma cell lines after chemotherapeutic agent treatment (2015) International Journal of Oncology, 46 (6), pp. 2299-2308.

Peira, E., Turci, F., Corazzari, I., Chirio, D., Battaglia, L., Fubini, B., Gallarate, M. The influence of surface charge and photo-reactivity on skin-permeation enhancer property of nano-TiO2 in ex vivo pig skin model under indoor light (2014) International Journal of Pharmaceutics, 467 (1-2), pp. 90-99.

Crudo, D., Bosco, V., Cavaglià, G., Mantegna, S., Battaglia, L., Cravotto, G. Process intensification in the food industry: Hydrodynamic and acoustic cavitation in fresh milk treatment (2014) Agro Food Industry Hi-Tech, 25 (1), pp. 55-59.

Gallarate, M., Serpe, L., Foglietta, F., Zara, G.P., Giordano, S., Peira, E., Chirio, D., Battaglia, L. Solid lipid nanoparticles loaded with fluorescent-labelled cyclosporine A: Anti-inflammatory activity in vitro (2014) Protein and Peptide Letters, 21 (11), pp. 1157-1162.

Gastaldi, L., Battaglia, L., Peira, E., Chirio, D., Muntoni, E., Solazzi, I., Gallarate, M., Dosio, F. Solid lipid nanoparticles as vehicles of drugs to the brain: Current state of the art (2014) European Journal of Pharmaceutics and Biopharmaceutics, 87 (3), pp. 433-444.

Battaglia, L., Gallarate, M., Peira, E., Chirio, D., Muntoni, E., Biasibetti, E., Capucchio, M.T., Valazza, A., Panciani, P.P., Lanotte, M., Schiffer, D., Annovazzi, L., Caldera, V., Mellai, M., Riganti, C. Solid lipid nanoparticles for potential doxorubicin delivery in glioblastoma treatment: Preliminary in vitro studies (2014) Journal of Pharmaceutical Sciences, 103 (7), pp. 2157-2165.

Chirio, D., Gallarate, M., Peira, E., Battaglia, L., Muntoni, E., Riganti, C., Biasibetti, E., Capucchio, M.T., Valazza, A., Panciani, P., Lanotte, M., Annovazzi, L., Caldera, V., Mellai, M., Filice, G., Corona, S., Schiffer, D. Positive-charged solid lipid nanoparticles as paclitaxel drug delivery system in glioblastoma treatment (2014) European Journal of Pharmaceutics and Biopharmaceutics, 88 (3), pp. 746-758.

Garbossa, D., Panciani, P.P., Angeleri, R., Battaglia, L., Tartara, F., Ajello, M., Agnoletti, A., Versari, P., Ducati, A., Fontanella, M., Spena, G. A retrospective two-center study of antiepileptic prophylaxis in patients with surgically treated high-grade gliomas (2013) Neurology India, 61 (2), pp. 131-137.

Gallarate, M., Chirio, D., Bussano, R., Peira, E., Battaglia, L., Baratta, F., Trotta, M. Development of O/W nanoemulsions for ophthalmic administration of timolol (2013) International Journal of Pharmaceutics, 440 (2), pp. 126-134.

Panciani, P.P., Fontanella, M., Tamagno, I., Battaglia, L., Garbossa, D., Inghirami, G., Fagioli, F., Pagano, M., Ducati, A., Lanotte, M. Stem cells based therapy in high grade glioma: Why the intraventricular route should be preferred? (2012) Journal of Neurosurgical Sciences, 56 (3), pp. 221-229.

Battaglia, L., Gallarate, M. Lipid nanoparticles: State of the art, new preparation methods and challenges in drug delivery (2012) Expert Opinion on Drug Delivery, 9 (5), pp. 497-508.

Battaglia, L., Peira, E., Sapino, S., Gallarate, M. Lipid nanosystems in topical PUVA therapy (2012) Journal of Dispersion Science and Technology, 33 (4), pp. 565-569.

Battaglia, L., D'Addino, I., Peira, E., Trotta, M., Gallarate, M. Solid lipid nanoparticles prepared by coacervation method as vehicles for ocular cyclosporine (2012) Journal of Drug Delivery Science and Technology, 22 (2), pp. 125-130.

Battaglia, L., Serpe, L., Muntoni, E., Zara, G., Trotta, M., Gallarate, M. Methotrexate-loaded SLNs prepared by coacervation technique: In vitro cytotoxicity and in vivo pharmacokinetics and biodistribution (2011) Nanomedicine, 6 (9), pp. 1561-1573.

Battaglia, L., Gallarate, M. New formulative strategies for lipid nano and microparticles preparation (2011) Recent Patents on Drug Delivery and Formulation, 5 (3), pp. 176-177.

Chirio, D., Gallarate, M., Peira, E., Battaglia, L., Serpe, L., Trotta, M. Formulation of curcumin-loaded solid lipid nanoparticles produced by fatty acids coacervation technique (2011) Journal of Microencapsulation, 28 (6), pp. 537-548.

Trotta, M., Carlotti, M.E., Gallarate, M., Zara, G.P., Muntoni, E., Battaglia, L. Insulin-loaded SLN prepared with the emulsion dilution technique: In vivo tracking of nanoparticles after oral administration to rats (2011) Journal of Dispersion Science and Technology, 32 (7), pp. 1041-1045.

Gallarate, M., Battaglia, L., Peira, E., Trotta, M. Peptide-loaded solid lipid nanoparticles prepared through coacervation technique (2011) International Journal of Chemical Engineering, art. no. 132435, .

Gallarate, M., Trotta, M., Battaglia, L., Chirio, D. Cisplatin-loaded SLN produced by coacervation technique (2010) Journal of Drug Delivery Science and Technology, 20 (5), pp. 343-347.

Bianco, M.A., Gallarate, M., Trotta, M., Battaglia, L. Amphotericin B loaded SLN prepared with the coacervation technique (2010) Journal of Drug Delivery Science and Technology, 20 (3), pp. 187-191.

Battaglia, L., Gallarate, M., Cavalli, R., Trotta, M. Solid lipid nanoparticles produced through a coacervation method (2010) Journal of Microencapsulation, 27 (1), pp. 78-85.

Gallarate, M., Trotta, M., Battaglia, L., Chirio, D. Preparation of solid lipid nanoparticles from W/O/W emulsions: Preliminary studies on insulin encapsulation (2009) Journal of Microencapsulation, 26 (5), pp. 394-402.

Carlotti, M.E., Ugazio, E., Sapino, S., Peira, E., Battaglia, L., Cavalli, R. Photodegradation of caffeic acid in W/O/W emulsions in the absence and in the presence of TiO2 (2008) Journal of Dispersion Science and Technology, 29 (10), pp. 1435-1444.

Battaglia, L., Trotta, M., Gallarate, M., Carlotti, M.E., Zara, G.P., Bargoni, A. Solid lipid nanoparticles formed by solvent-in-water emulsion-diffusion technique: Development and influence on insulin stability (2007) Journal of Microencapsulation, 24 (7), pp. 672-684.

Carlotti, M.E., Sapino, S., Trotta, M., Battaglia, L., Vione, D., Pelizzetti, E. Photostability and stability over time of retinyl palmitate in an O/W emulsion and in SLN introduced in the emulsion (2005) Journal of Dispersion Science and Technology, 26 (2), pp. 125-138.

Sapino, S., Carlotti, M.E., Pelizzetti, E., Vione, D., Trotta, M., Battaglia, L. Protective effect of SLNs encapsulation on the photodegradation and thermal degradation of retinyl palmitate introduced in hydroxyethylcellulose gel (2005) Journal of Drug Delivery Science and Technology, 15 (2), pp. 159-165.

Trotta, M., Cavalli, R., Carlotti, M.E., Battaglia, L., Debernardi, F. Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion-diffusion technique (2005) International Journal of Pharmaceutics, 288 (2), pp. 281-288.

Carlotti, M.E., Battaglia, L., Ugazio, E., Gallarate, M., Debernardi, F. Study on the release properties and stability of o/w emulsions containing salicylic acid and zinc oxide (2004) Journal of Drug Delivery Science and Technology, 14 (2), pp. 119-126.

Courses

• Chimica dei Prodotti Cosmetici (Tecniche Erboristiche) (FAR0256)
  Corso di Laurea in Tecniche Erboristiche

Research groups

• Innovative Pharmaceutical and Cosmetic Technology and Nanotechnology Group (i-PHARCOTEC)

Research projects

• An Innovative Nanotechnology for Glioma Chemotherapy
• NanoLipid@NasalDevice: Nanocarriers lipidici nasali come device per la prevenzione e il trattamento di patologie cerebrovascolari
• Preclinical study targeting mechanosensitive Ca2+ channels for Cerebral Cavernous Malformations therapy and early diagnosis - MECACCM

Activities in agenda

See my calendar

Academic bodies

• Consiglio di Dipartimento

Office hours

Su appuntamento (in presenza o in modalità di teleconferenza webex).